Correlation between Skeletal Muscle Calpain Activity and Growth Rate of Chicken.

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Muscle wasting in sepsis reflects activation of multiple proteolytic mechanisms, including lyosomal and ubiquitin-proteasome-dependent protein breakdown. Recent studies suggest that activation of the calpain system also plays an important role in sepsis-induced muscle wasting. Perhaps the most important consequence of calpain activation in skeletal muscle during sepsis is disruption of the sarc...

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Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration

Calpains are Ca(2+)-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys in humans), strongly suggesting a loss of proteolytic activity. CAPN6 is expressed predominantly ...

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ژورنال

عنوان ژورنال: Japanese poultry science

سال: 1994

ISSN: 0029-0254

DOI: 10.2141/jpsa.31.307